Streptomycin Biosynthesis and Metabolism

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Streptomycin Biosynthesis and Metabolism

Extracts of streptomycin-producing strains of Sfreptomyces phosphorylate dihydrostreptomycin (sfrepfidino)phosphate with adenosine 5’-triphosphate as the phosphoryl donor. The second phosphate is esterified with the dihydrostreptobiosamine moiety. Streptomycin (sfreptidino)phosphate was not phosphorylated under similar conditions. Because of its lability, the new enzyme that is responsible for ...

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Biosynthesis of Streptomycin

Streptomycin, the antibiotic produced by Streptomyces griseus, contains as a part of its structure a diguanidine derivative of scyllo-inositol called streptidine. Two major precursors of the streptidine portion of the molecule have now been defined, n-arginine and n-glucose (1, 2). Arginine plays a role in the formation of the guanidine side chains, whereas glucose is involved in the synthesis ...

متن کامل

Biosynthesis of Streptomycin

Streptomycin, the antibiotic produced by Streptomyces griseus, contains as a part of its structure a diguanidine derivative of scyllo-inositol called streptidine. Two major precursors of the streptidine portion of the molecule have now been defined, n-arginine and n-glucose (1, 2). Arginine plays a role in the formation of the guanidine side chains, whereas glucose is involved in the synthesis ...

متن کامل

Biosynthesis of Streptomycin

Streptomycin, the antibiotic produced by Streptomyces griseus, contains as a part of its structure a diguanidine derivative of scyllo-inositol called streptidine. Two major precursors of the streptidine portion of the molecule have now been defined, n-arginine and n-glucose (1, 2). Arginine plays a role in the formation of the guanidine side chains, whereas glucose is involved in the synthesis ...

متن کامل

Biosynthesis of Streptomycin

Streptomycin, the antibiotic produced by Streptomyces griseus, contains as a part of its structure a diguanidine derivative of scyllo-inositol called streptidine. Two major precursors of the streptidine portion of the molecule have now been defined, n-arginine and n-glucose (1, 2). Arginine plays a role in the formation of the guanidine side chains, whereas glucose is involved in the synthesis ...

متن کامل

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1970

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)62588-8